This is the fourth in a series of proceedings of the Combinatorial and Additive Number Theory (CANT) conferences, based on talks from the 2019 and 2020 workshops at the City University of New York. The latter was held online due to the COVID-19 pandemic, and featured speakers from North and South America, Europe, and Asia. The 2020 Zoom conference was the largest CANT conference in terms of the number of both lectures and participants. These proceedings contain 25 peer-reviewed and edited papers on current topics in number theory. Held every year since 2003 at the CUNY Graduate Center, the workshop surveys state-of-the-art open problems in combinatorial and additive number theory and related parts of mathematics. Topics featured in this volume include sumsets, zero-sum sequences, minimal complements, analytic and prime number theory, Hausdorff dimension, combinatorial and discrete geometry, and Ramsey theory. This selection of articles will be of relevance to both researchers and graduate students interested in current progress in number theory.