This volume features selected papers from The Fifteenth International Conference on Order Analysis and Related Problems of Mathematical Modeling, which was held in Vladikavkaz, Russia, on 15 - 20th July 2019. Intended for mathematicians specializing in operator theory, functional spaces, differential equations or mathematical modeling, the book provides a state-of-the-art account of various fascinating areas of operator theory, ranging from various classes of operators (positive operators, convolution operators, backward shift operators, singular and fractional integral operators, partial differential operators) to important applications in differential equations, inverse problems, approximation theory, metric theory of surfaces, the Hubbard model, social stratification models, and viscid incompressible fluids.