This book contains contributions from the participants of the research group hosted by the ZiF - Center for Interdisciplinary Research at the University of Bielefeld during the period 2013-2017 as well as from the conclusive conference organized at Bielefeld in December 2017. The contributions consist of original research papers: they mirror the scientific developments fostered by this research program or the state-of-the-art results presented during the conclusive conference. The volume covers current research in the areas of operator theory and dynamical systems on networks and their applications, indicating possible future directions. The book will be interesting to researchers focusing on the mathematical theory of networks; it is unique as, for the first time, continuous network models - a subject that has been blooming in the last twenty years - are studied alongside more classical and discrete ones. Thus, instead of two different worlds often growing independently without much intercommunication, a new path is set, breaking with the tradition. The fruitful and beneficial exchange of ideas and results of both communities is reflected in this book.