With the intriguing development of technologies in several industries along with the advent of accrescent and ubiquitous computational resources, it creates an ample number of opportunities to develop innovative intelligence technologies in order to solve the wide range of uncertainties, imprecision, and vagueness issues in various real-life problems. Hybridizing modern computational intelligence with traditional computing methods has attracted researchers and academicians to focus on developing innovative AI techniques using data science. International Conference on Data Science and Artificial Intelligence (ICDSAI) 2022, organized on April 23-24, 2022 by the Indian Institute of Technology, Patna at NITIE Mumbai (India) in collaboration with the International Association of Academicians (IAASSE) USA collected scientific and technical contributions with respect to models, tools, technologies, and applications in the field of modern Artificial Intelligence and Data Science, covering the entire range of concepts from theory to practice, including case studies, works-in-progress, and conceptual explorations.