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Fractional differentiation inequalities are by themselves an important area of research. They have many applications in pure and applied mathematics and many other applied sciences. One of the most important applications is in establishing the uniqueness of a solution in fractional differential equations and systems and in fractional partial differential equations. They also provide upper bounds to the solutions of the above equations. In this book the author presents the Opial, Poincaré, Sobolev, Hilbert, and Ostrowski fractional differentiation inequalities. Results for the above are derived using three different types of fractional derivatives, namely by Canavati, Riemann-Liouville and Caputo. The univariate and multivariate cases are both examined. Each chapter is self-contained. The theory is presented systematically along with the applications. The application to information theory is also examined. This monograph is suitable for researchers and graduate students in pure mathematics. Applied mathematicians, engineers, and other applied scientists will also find this book useful.